How puffs become cigarettes
Four steps, and none of the numbers in them is ours. First, how much of the liquid's nicotine one puff carries, in microlitres, for your kind of device. That is the lowest-to-highest spread of published measurements, each worked out by division alone: for the machine studies, nicotine in 15 puffs ÷ 15 ÷ the liquid's measured strength; for the study of people vaping their own devices, liquid used in 15 puffs ÷ 15 ÷ the liquid's density, taken from its measured glycerol and propylene glycol mix at 1.261 and 1.036 g/mL. That gives 2.1 to 5.4 microlitres for a disposable (five devices, Talih and colleagues, 2022), 1.3 to 7.2 for a pod or cartridge (JUUL in three studies, two cartridge users), 3.0 to 11.1 for a tank (seven users) and 16.1 to 26.7 for a sub-ohm or rebuildable device (three users).
Second, that volume × your strength in mg/mL is the nicotine a puff carries, and 93.8% of it counts as absorbed: the average share of inhaled nicotine that stayed in the body in St Helen and colleagues' 2016 study. Third, × your puffs a day. With a device label, puffs a day is the labelled puff count ÷ the days one device lasts, and when you give the liquid volume, neither end can pass the nicotine in the liquid you finish in a day, times the same 93.8%.
Fourth, cigarettes: the low end divides by 1.5 mg and the high end by 1 mg, the range for the systemic dose per cigarette in Benowitz, Hukkanen and Jacob's review. Puffs to one cigarette runs the other way: 1 mg over the strongest puff, 1.5 mg over the weakest. A percentage is read the way labels read it, 1% = 10 mg/mL.
What this does not do: it measures no puff, knows nothing about how long you draw, and says nothing about harm. The machine studies used 4-second puffs; people's own puffs vary, and one study found 15-puff yields moving more than 50-fold with puff length and power. The range is as wide as the evidence, which is the point of it.
Where this comes from
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1.
Electrical features, liquid composition and toxicant emissions from 'pod-mod'-like disposable electronic cigarettes — nicotine in 15 puffs and measured strength, five disposables and JUUL
Talih et al., Tobacco Control, 2022 (PubMed Central)
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2.
Characteristics and toxicant emissions of JUUL electronic cigarettes — 2.07 mg of nicotine in 15 puffs at 68.6 mg/mL
Talih et al., Tobacco Control, 2019 (PubMed Central)
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3.
A comparison of the electrical characteristics, liquid composition, and toxicant emissions of JUUL USA and JUUL UK e-cigarettes
Talih et al., Scientific Reports, 2020 (PubMed Central)
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4.
Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes — liquid used in 15 puffs by 13 people on their own devices; 93.8% of inhaled nicotine retained
St Helen et al., Addiction, 2016 (PubMed Central)
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5.
Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield
Talih et al., Nicotine & Tobacco Research, 2015 (PubMed Central)
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6.
Nicotine chemistry, metabolism, kinetics and biomarkers — systemic dose from cigarette smoking, 1 to 1.5 mg per cigarette
Benowitz, Hukkanen & Jacob, Handbook of Experimental Pharmacology, 2009 (PubMed Central)
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7.
Glycerol — density 1.2613 g/cm³ at 20 °C
PubChem, US National Library of Medicine
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8.
Propylene glycol — density 1.0361 g/cm³ at 20 °C
PubChem, US National Library of Medicine
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9.
E-cigarettes: regulations for consumer products — tanks of no more than 2 mL, e-liquid of no more than 20 mg/mL
UK Government guidance, GOV.UK
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10.
Vaping to quit smoking — vaping is less harmful than smoking and is not risk-free
NHS Better Health
Nothing on this page is medically reviewed and nothing above measures anything about you — it
explains a calculation. Where a number here is our own judgement rather than a published figure, the
note says so and cites nothing; where the health bodies disagree, it carries the disagreement.
Method last checked 28 September 2026.